Are Patients with Down Syndrome Predisposed to Retinal Neoplasms?

Adults with Down syndrome are predisposed to obstructive sleep apnoea/hypopnoea syndrome (OSAHS) due to overlap between the Down syndrome phenotype and OSAHS risk factors

Patients with Down syndrome in the coronavirus Pandemic (Covid 19)

Background and purpose: Coronavirus (QUID-19) is an infectious disease of the respiratory system that has been identified by the World Health Organization as an epidemic. Patients with Down syndrome are more likely to develop Quidd-19 disease with more severe complications due to the underlying comorbidities they have. The aim of this study was to evaluate the complications of Covid-19 disease...

Intracerebral haemorrhage in Down syndrome: protected or predisposed?

Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel walls of the cerebral microvasculature. The parenchymal plaque amyloid is thought to result in an early onset Alzheimer's disease (AD) dementia, a...

Are Communication Skills as effective factors on Sibling Relationships of Adolescents with Down Syndrome?

Objectives: Sibling relationships are often among the longest lasting relationships between people, and more than two-thirds of adolescents with siblings introduce their siblings as the most important people in their life. Therefore, the aim of this study was to evaluate the effectiveness of communication skills on sibling relationships among the adolescents with Down syndrome. Methods:  <a c...

Are Presynaptic Proteins Predisposed to Self-Assemble?

Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon.